It’s possible for a skeleton hand tattoo to represent many things, depending on the design and the images you choose to incorporate. It also largely depends on the mindset and feeling of the person deciding to move forward with a skeleton hand tattoo.
In general, skeletons are associated with death and the afterlife. That said, many people believe that they have more positive meanings. Some think that they represent a desire to live a life to the fullest, filled with renewal, and overcoming challenges as they appear.
Skeleton hand tattoos can also be a symbol of change. If you include other elements, the meaning can change slightly. For example, A clock could represent time running out or a snake might be intertwined which can be seen as a symbol of protection to ward off evil. Others might add a rose the represent the balance between life and death and beauty and pain.
What is most important is how the person with the skeleton hand tattoo views the significance.